UCSF Institute for Human Genetics

The core members of the IHG are engaged in research that spans the broad spectrum of human genetics, from basic science and technology development to clinical investigations to pharmacogenetics and population genetics to reproductive applications and outcomes. The following provides a brief outline of the variety and breadth of areas covered by the cadre of scientists and clinician-scientists that are our core members:

Cancer Genetics

Brain – Wiemels, Wiencke, Wrensch
Breast – Ziv
Leukemia – Wiemels
Lung – Wiencke, Wrensch
Prostate – Witte
Skin – Balmain, Cleaver, Epstein
Genetic Instability – Albertson, Wiemels
Cancer Syndromes - Rauen

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Immunogenetics

Asthma – Burchard, Ziv, Risch
HIV – Oksenberg
Inherited Immune Disorders - Puck

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Autoimmune Genetics

Autoimmune Lymphoproliferative Syndrome (ALPS) - Puck
Multiple Sclerosis – Hauser, Oksenberg, Fu, Risch
Rheumatoid Arthritis – Criswell
Systemic Lupus Erythematosus – Criswell

Neurogenetics

Movement Disorders – Ptacek, Risch
Epilepsy – Ptacek, Risch
Migraine – Ptacek
Neurodegenerative Disorders – Gitschier, Fu, Ptacek, Oksenberg, Cleaver
Tourette Syndrome - Mathews

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Psychiatric/Behavioral Genetics

Attention Deficit-Hyperactivity Disorder – Hamilton, Mathews
Autism – Hamilton, Risch
Panic Disorder – Hamilton
Circadian Rhythms – Fu, Ptacek, Hsueh
Perfect Pitch – Gitschier, Risch
Canine Models of Behavioral Disorders - Hamilton
Lauren Weiss - Autism

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Metabolic Disorders Genetics

Inborn Errors of Metabolism – Packman
Defects in Steroidogenesis – Miller
Obesity – Vaisse, Hsueh, Risch
Type 2 Diabetes – Vaisse, Hsueh, Risch

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Cardiovascular Disease Genetics

Hypertension – Risch
Lipidemia – Aouizerat, Risch
Atherosclerosis/Myocardial Infarction – Kan, Risch, Kwok, Rame
Human Heart Failure - Rame
Familial Cardiovascular Syndromes - Rame
G protein–coupled receptors (GPCRs) - Conklin

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Hematologic Genetics

Sickle Cell Disease – Kan
Thalassemia – Kan

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Reproductive Outcomes

Birth Defects – Slavotinek, Risch

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Developmental Genetics

Ahituv
Klein

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Genetics of Aging/Longevity

Hsueh, Ziv, Kwok

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Liver Disease Genetics

Cholestasis syndromes – Bull
Non-alcoholic fatty liver disease – Aouizerat

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Dermatologic Genetics

Collagen genes – Kwok

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Pharmacogenetics

Membrane Transporters – Giacomini, Kroetz, Burchard, Risch
Cytochrome P450 genes – Kroetz
Anti-depressant Response – Hamilton, Risch, Giacomini

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Technology Developments

Gene Therapy – Kan
Molecular Genetics/SNPs/Haplotypes – Kwok
CGH Arrays – Albertson, Pinkel
Statistical Genetics – Risch, Witte
Mouse Models of Human Disease – Balmain, Bull, Cleaver, Epstein,
Gitschier, Kan, Oksenberg, Ptacek, Reijo

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Population Genetics

Genetic Structure – Risch
Linkage Disequilibrium – Risch, Kwok, Burchard, Ziv
Genetic Admixture Analysis – Burchard, Ziv, Risch
Latino Population Genetics – Burchard
Jewish Genetics – Risch, Packman

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Newborn Screening - Puck

Severe Combined Immunodeficiency (SCID) - Puck

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