The Bruneau lab is interested in understanding the gene regulatory networks that control the differentiation and morphogenesis of the heart. They use mouse genetic models and genome editing in human induced pluripotent stem cells to modify transcriptional regulators and model disease. Amongst their interests are the actions of chromatin remodeling complexes and epigenetic regulators on cardiac genes and their role in heart development and function. They also wish to understanding interactions between disease-related transcription factors and chromatin modifying complexes, and their role in guiding the cellular regulation of important morphogenetic processes, such as cardiac chamber formation and septation. They have also been investigating the 3D organization of the genome and how this contributes to cardiac gene regulation.